{"created":"2023-11-01T07:12:43.794974+00:00","id":2000058,"links":{},"metadata":{"_buckets":{"deposit":"7a4b6910-7429-432a-848d-74488c0117bb"},"_deposit":{"created_by":13,"id":"2000058","owner":"13","owners":[13],"pid":{"revision_id":0,"type":"depid","value":"2000058"},"status":"published"},"_oai":{"id":"oai:jumonji-u.repo.nii.ac.jp:02000058","sets":["7:11:1698117040922"]},"author_link":[],"control_number":"2000058","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-28","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"36","bibliographicPageStart":"29","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"十文字学園女子大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Bulletin of Jumonji University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"コーヒーシルバースキンはコーヒー生豆を覆う薄皮であり，焙煎過程で生じる主要な副産物である。しかし，有効な利用方法が確立されておらず，コーヒー豆店などでは廃棄物として大量に処分されている。一方，3-ピリジノールはコーヒー豆の焙煎により生成する化合物であり，抗酸化作用や肝臓保護作用などの機能が報告されている。3-ピリジノールはコーヒー豆中だけでなく，コーヒーシルバースキンにも多く含有しており，単離・精製することができれば有効な廃棄物利用となる。本研究では，まず3-ピリジノールの定量的なHPLC 分析法を確立し，コーヒーシルバースキン中に含有する3-ピリジノールの含量を調べた。次に，シルバースキンから3-ピリジノールを単離する手法を開発した。最後に，3-ピリジノールがメラニン産生に及ぼす影響を調べるためにマウスB16メラノーマ細胞，ヒトHMV-Ⅱメラノーマ細胞および正常ヒト皮膚メラノモデルを用いて検討した。その結果，シルバースキンから単離した3-ピリジノールは動物細胞においてメラノサイトを活発化し，メラニン産生を促進する効果が認められた。これらのことから，3-ピリジノールは新たな白斑改善剤や白髪予防剤，日焼け促進剤，そして有効な廃物利用に繋がることが期待される。【査読あり】","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2424-0591","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 章夫","creatorNameLang":"ja"},{"creatorName":"ワタナベ, アキオ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"加藤, 毅","creatorNameLang":"ja"},{"creatorName":"カトウ, ツヨシ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"衛藤, 未侑","creatorNameLang":"ja"},{"creatorName":"エトウ, ミユ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"小林, 亘","creatorNameLang":"ja"},{"creatorName":"コバヤシ, ワタル","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"倉若, 美咲樹","creatorNameLang":"ja"},{"creatorName":"クラワカ, ミサキ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"三嶋, 隆","creatorNameLang":"ja"},{"creatorName":"ミシマ, タカシ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"仲川　清隆","creatorNameLang":"ja"},{"creatorName":"ナカガワ, キヨタカ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"WATANABE, Akio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"KATO, Tsuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ETO, Miyu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"KOBAYASHI, Wataru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"KURAWAKA, Misaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"MISHIMA, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"NAKAGAWA, Kiyotaka","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-11-02"}],"displaytype":"detail","filename":"紀要53号-03　研究ノート　渡辺章夫.pdf","filesize":[{"value":"6.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://jumonji-u.repo.nii.ac.jp/record/2000058/files/紀要53号-03　研究ノート　渡辺章夫.pdf"},"version_id":"53ba3af0-6cea-4556-8b0f-7dfecf3703ef"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"コーヒーシルバースキンに含まれる3-ピリジノールの単離精製とメラニン産生に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"コーヒーシルバースキンに含まれる3-ピリジノールの単離精製とメラニン産生に及ぼす影響","subitem_title_language":"ja"},{"subitem_title":"Purification of 3-pyridinol from coffee silver-skin and effect on melanogenesis","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"13","path":["1698117040922"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-11-02"},"publish_date":"2023-11-02","publish_status":"0","recid":"2000058","relation_version_is_last":true,"title":["コーヒーシルバースキンに含まれる3-ピリジノールの単離精製とメラニン産生に及ぼす影響"],"weko_creator_id":"13","weko_shared_id":-1},"updated":"2023-11-02T08:10:06.787298+00:00"}